Journal: Frontiers in Cell and Developmental Biology

Article Title: Breaking the mold: 3D cell cultures reshaping the future of cancer research

doi: 10.3389/fcell.2024.1507388

Figure Lengend Snippet: Brief description and main advantages and limitations of the most used cancer models.

Article Snippet: Microfluidic device designed and fabricated at AIM BIOTECH , Human-derived spheroids from breast cancer individuals , Assess the effect of inter and intra-heterogeneity of spheroids in cell viability and migration behavior , .

Techniques: Cell Culture, Diffusion-based Assay, In Vivo, Control, Derivative Assay, Drug discovery, Shear, Drug Transport Assay, Biomarker Discovery

Journal: Frontiers in Cell and Developmental Biology

Article Title: Breaking the mold: 3D cell cultures reshaping the future of cancer research

doi: 10.3389/fcell.2024.1507388

Figure Lengend Snippet: Examples of ToC applications in drug screening, cancer research and personalized medicine.

Article Snippet: Microfluidic device designed and fabricated at AIM BIOTECH , Human-derived spheroids from breast cancer individuals , Assess the effect of inter and intra-heterogeneity of spheroids in cell viability and migration behavior , .

Techniques: Drug discovery, Functional Assay, Migration

Journal: Neural Regeneration Research

Article Title: Nerve growth factor-basic fibroblast growth factor poly-lactide co-glycolid sustained-release microspheres and the small gap sleeve bridging technique to repair peripheral nerve injury

doi: 10.4103/1673-5374.344842

Figure Lengend Snippet: The schematic diagram of the drug screening biomimetic microfluidic chip. bFGF: Basic fibroblast growth factor; CCU: cell culture unit; CGG: concentration gradient generator; NGF: nerve growth factor.

Article Snippet: In this study, we used our designed drug screening biomimetic microfluidic chip to screen the optimal combination and concentration of NGF and bFGF for promoting peripheral nerve regeneration and repair.

Techniques: Drug discovery, Cell Culture, Concentration Assay

Journal: Neural Regeneration Research

Article Title: Nerve growth factor-basic fibroblast growth factor poly-lactide co-glycolid sustained-release microspheres and the small gap sleeve bridging technique to repair peripheral nerve injury

doi: 10.4103/1673-5374.344842

Figure Lengend Snippet: Virtual model and schematic of a drug screening biomimetic microfluidic chip. The chip comprises an upstream CGG and downstream parallel CCU, and includes two inlet ports, one liquid outlet, one drug CGG and eight cell culture chambers. CCU: Cell culture unit; CGG: concentration gradient generator.

Article Snippet: In this study, we used our designed drug screening biomimetic microfluidic chip to screen the optimal combination and concentration of NGF and bFGF for promoting peripheral nerve regeneration and repair.

Techniques: Drug discovery, Cell Culture, Concentration Assay

Journal: Neural Regeneration Research

Article Title: Nerve growth factor-basic fibroblast growth factor poly-lactide co-glycolid sustained-release microspheres and the small gap sleeve bridging technique to repair peripheral nerve injury

doi: 10.4103/1673-5374.344842

Figure Lengend Snippet: Identification of drug concentration gradients of the biomimetic microfluidic chips. (A) Images 1–8 represent eight concentration gradients (more details of concentrations are shown in ). (B) The difference between the theoretical and experimental data of a concentration gradient generator. Data are expressed as mean ± SD. The study was repeated three times.

Article Snippet: In this study, we used our designed drug screening biomimetic microfluidic chip to screen the optimal combination and concentration of NGF and bFGF for promoting peripheral nerve regeneration and repair.

Techniques: Concentration Assay

Journal: Neural Regeneration Research

Article Title: Nerve growth factor-basic fibroblast growth factor poly-lactide co-glycolid sustained-release microspheres and the small gap sleeve bridging technique to repair peripheral nerve injury

doi: 10.4103/1673-5374.344842

Figure Lengend Snippet: Screening of the drug concentration in primary Schwann cells. (A) Live and dead cell staining of rat Schwann cells under eight different NGF/bFGF drug concentrations on the microfluidic chip. Green is AO stained cells (live), red is PI stained cells (dead). The cell number and proliferation rate of Schwann cells gradually increased from the 1 st chamber to the 4 th chamber, and gradually decreased from the 4 th chamber to the 8 th chamber, reaching a peak in the 4 th chamber (22.86 ng/mL NGF combined with 4.29 ng/mL bFGF). Scale bars: 25 μm. (B) Cell proliferation rate (cell number after culture with NGF/bFGF/initially implanted cell number × 100) under eight different concentrations. (C) Cell number after culture with NGF/bFGF under eight different drug concentrations. Data are expressed as mean ± SD. The above experiments were independently repeated three times. * P < 0.05, vs . other groups (one-way analysis of variance followed by Bonferroni post hoc test). 1–8: Cell culture chambers. AO: Acridine orange solution; bFGF: basic fibroblast growth factor; NGF: nerve growth factor; PI: propidium iodide.

Article Snippet: In this study, we used our designed drug screening biomimetic microfluidic chip to screen the optimal combination and concentration of NGF and bFGF for promoting peripheral nerve regeneration and repair.

Techniques: Concentration Assay, Staining, Cell Culture

Journal: ACS Omega

Article Title: Advances and Applications of Micro- and Mesofluidic Systems

doi: 10.1021/acsomega.4c10999

Figure Lengend Snippet: Substrate materials used in microfluidic chips.

Article Snippet: An acoustic focusing device was incorporated to collect microplastics by designing a Pyrex glass microfluidic chip with channels 707 μm wide and 505 μm deep.,

Techniques:

Journal: ACS Omega

Article Title: Advances and Applications of Micro- and Mesofluidic Systems

doi: 10.1021/acsomega.4c10999

Figure Lengend Snippet: Applications of microfluidics in biosensing, including medical diagnostics, cell analysis, drug screening, and biomolecular detection.

Article Snippet: An acoustic focusing device was incorporated to collect microplastics by designing a Pyrex glass microfluidic chip with channels 707 μm wide and 505 μm deep.,

Techniques: Cell Analysis, Drug discovery

Journal: ACS Omega

Article Title: Advances and Applications of Micro- and Mesofluidic Systems

doi: 10.1021/acsomega.4c10999

Figure Lengend Snippet: Ranking of the Top 10 Micro and Mesofluidic Systems Articles

Article Snippet: An acoustic focusing device was incorporated to collect microplastics by designing a Pyrex glass microfluidic chip with channels 707 μm wide and 505 μm deep.,

Techniques: Cell Culture, In Vitro, Single-cell Analysis

Journal: ACS Omega

Article Title: Advances and Applications of Micro- and Mesofluidic Systems

doi: 10.1021/acsomega.4c10999

Figure Lengend Snippet: Materials Used in Micro and Mesofluidic Systems

Article Snippet: An acoustic focusing device was incorporated to collect microplastics by designing a Pyrex glass microfluidic chip with channels 707 μm wide and 505 μm deep.,

Techniques: Membrane, Filtration